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Professors Chris Garland and Kim Dora are leading authors on a new paper published this week in the journal 'Science Signaling' entitled "Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles". Research conducted by the group found that Ca2+ entry into vascular smooth muscle activates Ca2+ signaling in the endothelium to protect tissue blood flow. These results resolve a long-standing controversy over how vascular smooth muscle cells communicate with endothelial cells to trigger feedback vasodilation.

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New Akerman group paper reveals links between sleep, synaptic inhibition, and the plastic changes that underlie learning in the brain

Pharmacology researchers have discovered a key mechanism linking sleep and wake to synaptic plasticity in the brain, shedding light on how learning and memory may be affected by rest. Their study, published by Alfonsa et al. in the journal Current Biology, reveals that intracellular chloride levels shift during sleep and wakefulness, influencing synaptic plasticity processes in the brain’s cortex.