Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis.

Zi M.; Kimura TE.; Liu W.; Jin J.; Higham J.; Kharche S.; Hao G.; Shi Y.; Shen W.; Prehar S.; Mironov A.; Neyses L.; Bierhuizen MFA.; Boyett MR.; Zhang H.; Lei M.; Cartwright EJ.; Wang X.

Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis.

Zi M., Kimura TE., Liu W., Jin J., Higham J., Kharche S., Hao G., Shi Y., Shen W., Prehar S., Mironov A., Neyses L., Bierhuizen MFA., Boyett MR., Zhang H., Lei M., Cartwright EJ., Wang X.

Original publication

DOI

10.1074/jbc.M111.228791

Type

Journal article

Journal

J Biol Chem

Publication Date

20/05/2011

Volume

286

Pages

17821 - 17830

Keywords

Animals, Arrhythmogenic Right Ventricular Dysplasia, Connexin 43, Gene Expression Regulation, MAP Kinase Kinase 4, Membrane Proteins, Mice, Mice, Transgenic, Myocytes, Cardiac, Phosphoproteins, Rats, Response Elements, Zonula Occludens-1 Protein