Synthesis of NAADP-AM as a membrane-permeant NAADP analog.
Galione A., Chuang K-T., Funnell TM., Davis LC., Morgan AJ., Ruas M., Parrington J., Churchill GC.
Nicotinic acid adenine dinucleotide phosphate (NAADP), like the other major messengers for Ca²⁺ mobilization, is passively membrane-impermeant. Instead, a cell-permeant acetoxymethyl ester derivative of NAADP (NAADP-AM) can be synthesized as described here and used to study NAADP-mediated Ca²⁺ release.