4 March 2020
Oxford Department of Pharmacology has been judged best in the world for the second year in a row in the QS World Rankings, published today.
Pharmacology Workshop Manager, John Harris, receives Honorary Degree in recognition of his 50 years of service
2 March 2020
John Harris, who started work in the Department of Pharmacology at the University of Oxford in 1969, was awarded an MA by the Vice-Chancellor Louise Richardson at a ceremony in the Sheldonian Theatre on Saturday 29 February 2020. John was described at the ceremony as "an essential pillar on whom to rely, to lean on in times of need, a craftsman of skill and imagination, a stalwart friend and steward to some of our most important scientific endeavours".
6 January 2020
A collaboration between the Russell group (Chemistry and Pharmacology) and the Davies group (Physiology, Anatomy and Genetics) has identified, via a chemical proteomics and phenotypic profiling strategy, the arylhydrocarbon receptor (AhR) as the molecular target of ezutromid, the utrophin modulator that recently completed a Phase 2 clinical trial in Duchenne muscular dystrophy patients.
11 November 2019
The Department of Pharmacology is seeking to appoint up to two Career Development Fellows by early 2020. Aimed at outstanding experienced and early career researchers, these posts will provide space, access to facilities and support to enable the postholders to establish their own independent research programme.
11 June 2019
Minas Salib, in the group led by Tim Viney and Peter Somogyi, has discovered a new type of neuronal pathway that may be important in memory. For the encoding and recall of episodic memories, nerve cells in the cerebral cortex are activated in precisely timed sequences. Rhythmicity facilitates the coordination of neuronal activity and these rhythms are detected as oscillations of different frequencies, such as 5–12 Hz theta oscillations. Degradation of these rhythms, such as through neurodegeneration, causes memory deficits. The medial septum, a part of the basal forebrain that innervates the hippocampal formation, contains neurons that fire with a high degree of rhythmicity (HRNs) and others that fire with a low degree of rhythmicity (LRNs). These distinct types of neuron may contribute differentially to the coordination of cortical neuronal activity. Minas and colleagues discovered that GABAergic LRNs preferentially innervate the dentate gyrus and the CA3 area of the hippocampus, regions important for episodic memory. These neurons act in parallel with the HRNs mostly via transient inhibition of inhibitory neurons. A figure from the paper describing these results was chosen to illustrate the front cover of the 5 June issue of Journal of Neuroscience.
1 May 2019
The Department is delighted to congratulate one of our visiting professors, Mark Nelson of the University of Vermont, on his election as a Member of the National Academy of Sciences, USA.