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TPC1-dependent control of endosomal pH and transferrin uptake determines cellular iron status.

Journal article

Deutsch R. et al, (2026), Proc Natl Acad Sci U S A, 123

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy.

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Xu H. et al, (2026), Adv Sci (Weinh)

Discovery of Stereoselective Targeted Covalent Inhibitors of the RAB27-Effector Protein–Protein Interaction

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De Vita E. et al, (2026), Journal of the American Chemical Society

Large amyloid plaques associate with early behavioral alterations in 6-month-old APPswe/PS1dE9 mice.

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Sitdikova K. et al, (2026), J Neuropathol Exp Neurol

Endosomal TPC1-mediated Ca2+ nanodomains regulate transferrin receptor trafficking and iron homeostasis.

Journal article

Burton WJ. et al, (2026), Proc Natl Acad Sci U S A, 123

Varicose projection astrocytes: Conserved reactive cells in brain pathology.

Journal article

Ciani C. et al, (2026), Sci Adv, 12

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