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Several studies have shown an association between homocysteine concentration and cognitive performance or cerebral white matter lesions. However, variations in genes encoding for enzymes and other proteins that play a role in homocysteine metabolism have hardly been evaluated in relation to these outcome measures. In the population-based Rotterdam Scan Study, we examined the association of seven polymorphisms of genes involved in homocysteine metabolism (MTHFR 677C>T, MTHFR 1298A>C, RFC 80G>A, TC 776C>G, MTR 2756A>G, MTRR 66A>G, and CBS 844ins68) with plasma total homocysteine, cognitive performance, and cerebral white matter lesions among 1011 non-demented elderly participants. Of all the studied polymorphisms, only MTHFR 677C>T was associated with homocysteine concentration. No significant relationship was observed for any of the polymorphisms with cognitive performance or severity of cerebral white matter lesions.

Original publication

DOI

10.1016/j.neurobiolaging.2008.10.004

Type

Journal article

Journal

Neurobiol Aging

Publication Date

11/2010

Volume

31

Pages

2020 - 2022

Keywords

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase, Aged, Aged, 80 and over, Aging, Brain, Cognition, Cross-Sectional Studies, Cystathionine beta-Synthase, Ferredoxin-NADP Reductase, Homocysteine, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Middle Aged, Nerve Fibers, Myelinated, Reduced Folate Carrier Protein, Transcobalamins