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There are over 40 human disease states that are caused by defects in various aspects of lysosomal function. Over the past two decades there has been dramatic progress in the development and evaluation of therapies for lysosomal storage disorders, several of which are now in routine clinical use or in clinical trials. The greatest current challenge is in developing effective therapies for treating the CNS manifestations of these complex disorders. In this article, we will review the current therapies/approaches being considered for treating lysosomal storage diseases and give a perspective on the scientific, medical, social and ethical issues they raise.

Original publication

DOI

10.1016/j.bbamcr.2008.08.009

Type

Journal article

Journal

Biochim Biophys Acta

Publication Date

04/2009

Volume

1793

Pages

737 - 745

Keywords

Central Nervous System Diseases, Enzyme Stability, Genetic Therapy, Humans, Lysosomal Storage Diseases, Mass Screening