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Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

Original publication

DOI

10.1016/j.brainres.2008.05.019

Type

Journal

Brain Res

Publication Date

24/07/2008

Volume

1221

Pages

93 - 97

Keywords

Action Potentials, Animals, Denervation, Dopamine, Electron Transport Complex IV, Energy Metabolism, Male, Mesencephalon, Neurons, Oxidopamine, Parkinsonian Disorders, Raphe Nuclei, Rats, Rats, Sprague-Dawley, Serotonin, Sympatholytics, Synaptic Transmission, Up-Regulation