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The induction and maintenance of synaptic plasticity is well established to be a Ca2+-dependent process. The use of fluorescent imaging to monitor changes [Ca2+]i in neurones has revealed a diverse array of signaling patterns across the different compartments of the cell. The Ca2+ signals within these compartments are generated by voltage or ligand-gated Ca2+ influx, and release from intracellular stores. The changes in [Ca2+]i are directly linked to the activity of the neurone, thus a neurone's input and output is translated into a dynamic Ca2+ code. Despite considerable progress in measuring this code much still remains to be determined in order to understand how the code is interpreted by the Ca2+ sensors that underlie the induction of compartment-specific plastic changes.

Original publication

DOI

10.1016/j.ceca.2005.06.013

Type

Journal article

Journal

Cell Calcium

Publication Date

09/2005

Volume

38

Pages

355 - 367

Keywords

Animals, Calcium, Calcium Signaling, Dendritic Spines, Humans, Long-Term Potentiation, Long-Term Synaptic Depression, Neuronal Plasticity, Synapses