Development of an inhibitor of the mutagenic SOS response that suppresses the evolution of quinolone antibiotic resistance
Bradbury JD., Hodgkinson T., Thomas AM., Tanwar O., La Monica G., Rogga VV., Mackay LJ., Taylor EK., Gilbert K., Zhu Y., Sefton AY., Edwards AM., Gray-Hammerton CJ., Smith GR., Roberts PM., Walsh TR., Lanyon-Hogg T.
Bacterial DNA-damage repair activates the SOS response, which promotes hypermutation and antibiotic resistance. SAR investigation identified OXF-077, a small molecule DNA-repair and SOS-response inhibitor that suppresses resistance evolution.