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Bacterial DNA-damage repair activates the SOS response, which promotes hypermutation and antibiotic resistance. SAR investigation identified OXF-077, a small molecule DNA-repair and SOS-response inhibitor that suppresses resistance evolution.

Original publication

DOI

10.1039/d4sc00995a

Type

Journal article

Journal

Chemical Science

Publisher

Royal Society of Chemistry (RSC)

Publication Date

2024