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Sea urchin eggs have been an indispensable model system for studying egg activation and ionic signalling for at least a century. Instrumental in the discovery of two Ca(2+)-mobilizing second messengers, cyclic ADP-ribose and NAADP, the sea urchin has revolutionized cell biology for all phyla. This review attempts to summarize what we currently know about egg acidic vesicles in the context of Ca(2+) signalling. The dynamics of Ca(2+) storage, Ca(2+) mobilization, proton fluxes and two-pore channels will be discussed.

Original publication

DOI

10.1016/j.ceca.2010.12.007

Type

Journal article

Journal

Cell Calcium

Publication Date

08/2011

Volume

50

Pages

147 - 156

Keywords

Acids, Animals, Antiporters, Calcium, Calcium Channels, Calcium Signaling, Calcium-Transporting ATPases, Cation Transport Proteins, Cyclic ADP-Ribose, Cytoplasmic Vesicles, Fertilization, Hydrogen-Ion Concentration, NADP, Ovum, Sea Urchins