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Cerebellar granule cells are often used as a model system for the study of neuronal development, function and pathology, including the analysis of activity-dependent survival/apoptosis of neurons and the mechanisms of neuroprotection. Cerebellar granule cells are generated postnatally and constitute the largest homogeneous neuronal population of the mammalian brain. In addition, cerebellar granule cells cultured in vitro develop characteristics of mature cerebellar granule cells seen in vivo, such as an extensive neuritic network, expression of excitatory amino acid receptors and production and release of -L: glutamate. Taken together, these features make cerebellar granule cells a unique model system that has been extensively characterised and used for in vitro studies.

Original publication

DOI

10.1007/978-1-59745-019-5_17

Type

Journal article

Journal

Methods Mol Biol

Publication Date

2010

Volume

633

Pages

233 - 239

Keywords

Animals, Cell Culture Techniques, Cell Separation, Cerebellum, Dissection, Mice, Neurons, Rats, Trypsin