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Axo-axonic interneurons, innervating exclusively axon initial segments, and parvalbumin-expressing basket interneurons, targeting somata, dendrites, and spines of pyramidal cells, have been proposed to control neuronal activity in prefrontal circuits. We recorded the spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo-axonic cells increase their firing during tail pinch-induced brain state-activation. In addition, axo-axonic cells differ from other GABAergic parvalbumin-expressing cells in their spike timing during DOWN- to UP-state transitions of slow oscillations and in their coupling to gamma and spindle oscillations. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks.

Original publication

DOI

10.1523/JNEUROSCI.3475-12.2012

Type

Journal article

Journal

J Neurosci

Publication Date

14/11/2012

Volume

32

Pages

16496 - 16502

Keywords

Animals, Axons, Dendrites, Electrophysiological Phenomena, Evoked Potentials, Immunohistochemistry, Interneurons, Nerve Net, Parvalbumins, Physical Stimulation, Prefrontal Cortex, Pyramidal Cells, Rats, Rats, Sprague-Dawley