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Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in lysosomal enzymes, but also in some non-enzymatic lysosomal proteins, which lead to abnormal storage of macromolecular substrates. Valuable insights into lysosome functions have emerged from research into these diseases. In addition to primary lysosomal dysfunction, cellular pathways associated with other membrane-bound organelles are perturbed in these disorders. Through selective examples, we illustrate why the term "cellular storage disorders" may be a more appropriate description of these diseases and discuss therapies that can alleviate storage and restore normal cellular function.

Original publication

DOI

10.1083/jcb.201208152

Type

Journal article

Journal

J Cell Biol

Publication Date

26/11/2012

Volume

199

Pages

723 - 734

Keywords

Animals, Cell Biology, Humans, Lysosomal Storage Diseases, Lysosomes, Models, Biological, Phenotype