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ATP-sensitive potassium (KATP) channels are inhibited by intracellular ATP and activated by MgADP. As a consequence, they couple the metabolic state of the cell to its electrical activity. In pancreatic Beta-cells KATP channels regulate glucose-dependent insulin secretion and are the target for sulphonylurea drugs clinically employed in the treatment of type 2 diabetes. This review discusses recent advances in our understanding of the role of KATP channels in permanent neonatal diabetes mellitus.

Original publication

DOI

10.1159/000111059

Type

Journal article

Journal

Endocr Dev

Publication Date

2007

Volume

11

Pages

70 - 82

Keywords

Diabetes Mellitus, Humans, Infant, Newborn, Insulin-Secreting Cells, KATP Channels, Models, Biological, Models, Molecular, Mutation