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Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotective in models of combined oxygen/glucose deprivation and N-methyl-D-aspartate toxicity, but no potentiation was observed at low IL-1 concentrations. Both protective and toxic effects of IL-1 were fully antagonized by IL-1 receptor antagonist. These data demonstrate that the effects of IL-1 on neuronal injury are complex, and may be directly related to the injury paradigm studied.

Type

Journal article

Journal

Neurosci Lett

Publication Date

01/06/2001

Volume

305

Pages

29 - 32

Keywords

Animals, Brain Ischemia, Culture Techniques, Dose-Response Relationship, Drug, Glucose, Hippocampus, Hypoxia, Interleukin 1 Receptor Antagonist Protein, Interleukin-1, N-Methylaspartate, Nerve Degeneration, Neurons, Neuroprotective Agents, Neurotoxins, Osmolar Concentration, Rats, Rats, Wistar, Sialoglycoproteins