Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The environment of the brain is controlled by a sophisticated endothelial barrier that prevents the free entry of solutes from the blood. It is commonly assumed that this blood-brain barrier (BBB) also prevents the entry of leukocytes into the central nervous system. However, recent evidence in animal models shows that this is not the case, and leukocytes can cross an intact BBB during health and disease. Indeed, in many neurological diseases, including Alzheimer's disease, prion diseases and AIDS-related dementia, leukocytes enter the brain parenchyma without concomitant BBB breakdown. Current research is concentrating on factors that control the integrity of the BBB and the mechanisms that leukocytes use to enter the brain.

Original publication

DOI

10.1016/S1357-4310(97)01077-0

Type

Journal article

Journal

Mol Med Today

Publication Date

08/1997

Volume

3

Pages

335 - 341

Keywords

Animals, Blood-Brain Barrier, Disease Models, Animal, Humans, Inflammation, Leukocytes, Mice, Nervous System Diseases, Rats