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We investigated a possible relationship between apoptosis induction by fenretinide (4HPR) and the expression of a group of genes thought to be essential in morphogenesis and development, the DLX genes. We analyzed their expression under normal conditions or upon 4HPR stimulation in several tumor cell lines. We show that DLX2, DLX3 and DLX4 were expressed at higher levels in cell lines which where more sensitive to apoptotic induction, whereas DLX 5 and 6 appeared to segregate in a distinct functional compartment. Our data support the notion that DLX2, 3, 4 genes could participate in the control of 4HPR-mediated apoptosis, making them important molecules for the monitoring of therapy efficacy in cancer patients.

Type

Journal

Oncol Rep

Publication Date

07/2003

Volume

10

Pages

973 - 977

Keywords

Antineoplastic Agents, Apoptosis, Cell Cycle, DNA-Binding Proteins, Fenretinide, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, Humans, Neoplasms, Proto-Oncogene Proteins c-bcl-2, RNA, Messenger, RNA, Neoplasm, Transcription Factors, Tumor Cells, Cultured, bcl-X Protein