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The parallel asymmetric synthesis of an array of 30 β-amino acids of high enantiomeric purity using the conjugate addition of homochiral lithium N-benzyl-N-(α-methylbenzyl)amide as the key step is accomplished. The experimental simplicity and highly practical nature of the protocol is demonstrated by the efficient parallel conversion of 15 α,β-unsaturated esters to both enantiomeric series of the corresponding β-amino acids in high overall yields and selectivities with minimal purification involved in each step of the reaction protocol. © 2007 Elsevier Ltd. All rights reserved.

Original publication

DOI

10.1016/j.tetasy.2007.06.008

Type

Journal article

Journal

Tetrahedron Asymmetry

Publication Date

17/07/2007

Volume

18

Pages

1554 - 1566