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The axonal targets of perisomatic targeting interneurons make them ideally suited to synchronize excitatory neurons. As such they have been implicated in rhythm generation of network activity in many brain regions including the hippocampus. However, several recent publications indicate that their roles extend beyond that of rhythm generation. Firstly, it has been shown that, in addition to rhythm generation, GABAergic perisomatic inhibition also serves as a current generator contributing significantly to hippocampal oscillatory EEG signals. Furthermore, GABAergic interneurons have a previously unrecognized role in the initiation of hippocampal population bursts, both in the developing and adult hippocampus. In this review, we describe these new observations in detail and discuss the implications they have for our understanding of the mechanisms underlying physiological and pathological hippocampal network activities. This review is part of the Frontiers in Cellular Neuroscience's special topic entitled "GABA signaling in health and disease" based on the meeting at the CNCR Amsterdam.

Original publication

DOI

10.3389/fncel.2010.00026

Type

Journal

Front Cell Neurosci

Publication Date

2010

Volume

4

Keywords

GABA, gamma oscillation, hippocampus, inhibition, network oscillation, perisomatic targeting interneuron, population burst, sharp wave-ripple