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2- and 3-dimensional confocal imaging of Fluo-4 loaded ureteric microvesells in situ allowed us to demonstrate distinct morphology, Ca2+ signalling and contractility in myocytes of arcade arterioles and pericytes of arcade venules. In myocytes and pericytes, Ca2+ signals arise exclusively from Ca2+ release from the sarcoplasmic reticulum through inositol 1,4,5-trisphosphate receptors. 2+ transients in pericytes are less oscillatory, slower and longer-lasting than those in myocytes. The data obtained suggest differences in the mechanisms controlling local blood flow in precapillary arterioles and postcapillary venules.

Type

Journal article

Journal

Ukrain'skyi Biokhimichnyi Zhurnal

Publication Date

19/12/2013

Volume

85

Pages

129 - 133