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Extracellular stimuli evoke the synthesis of intracellular second messengers, several of which couple to the release of Ca(2+)from Ca(2+)-storing organelles via activation of cognate organellar Ca(2+)-channel complexes. The archetype is the inositol 1,4,5-trisphosphate (IP3) and IP3receptor (IP3R) on the endoplasmic reticulum (ER). A less understood, parallel Ca(2+)signalling cascade is that involving the messenger nicotinic acid adenine dinucleotide phosphate (NAADP) that couples to Ca(2+)release from acidic Ca(2+)stores [e.g. endo-lysosomes, secretory vesicles, lysosome-related organelles (LROs)]. NAADP-induced Ca(2+)release absolutely requires organellar TPCs (two-pore channels). This review discusses how ER and acidic Ca(2+)stores physically and functionally interact to generate and shape global and local Ca(2+)signals, with particular emphasis on the two-way dialogue between these two organelles.

Original publication

DOI

10.1042/BST20150290

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

15/04/2016

Volume

44

Pages

546 - 553

Keywords

Ca2+, IP3, Lysosome, NAADP, TPC, endoplasmic reticulum, Acids, Animals, Calcium, Calcium Signaling, Endoplasmic Reticulum, Hydrogen-Ion Concentration, Organelles