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A general preparation of 2-substituted indoles starting from functionalized 2-alkynylanilines has been developed. This base mediated reaction has also been used to synthesize the heterocyclic core of the marine alkaloid hinckdentine A. Furthermore the reaction was successfully adapted to the solid phase. Benzofurans and isoindolones could also be prepared with this method. © 2003 Elsevier Science Ltd. All rights reserved.

Original publication

DOI

10.1016/S0040-4020(03)00073-5

Type

Journal article

Journal

Tetrahedron

Publication Date

24/02/2003

Volume

59

Pages

1571 - 1587