Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The synthesis of 1-O-[(3S,4R)-3-hydroxytetrahydrofuran-4-yl]-alpha-D-glucopyranosid e 3,4,3'-trisphosphate (7), a novel Ca2+ mobilising agonist at the Ins(1,4,5)P3 receptor, designed by excision of two motifs of adenophostin A is reported, defining a potential minimal structure for potent glucopyranoside-based agonists of Ins(1,4,5)P3 receptors.

Type

Journal article

Journal

Bioorg Med Chem Lett

Publication Date

08/02/1999

Volume

9

Pages

453 - 458

Keywords

Adenosine, Animals, Calcium, Carbohydrate Conformation, Cells, Cultured, Furans, Glucosephosphates, Glycosides, Inositol 1,4,5-Trisphosphate, Liver, Molecular Mimicry, Rats