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As controversial as ever is the role of D-myo-inositol- 1,3,4,5-tetrakisphosphate (1) in intracellular signaling. A new synthetic strategy that makes minimal use of protecting groups allows rapid, direct access not only to pure 1 in the amounts required for cocrystallographic and NMR studies with its recently identified macromolecular targets, but also to the little-known L enantiomer, which is invaluable as a control in radioligand binding and functional studies.


Journal article


Angewandte Chemie - International Edition in English

Publication Date





1472 - 1474