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Syntheses of regiochemically and structurally modified analogues of D-myo-inositol 1,4,5-trisphosphate are described to give second messenger mimics, enzyme inhibitors and receptor antagonists, demonstrating new leads for the design of agents to interfere with a key pathway of signal transduction.

Type

Journal article

Journal

Phosphorus, Sulfur and Silicon and Related Elements

Publication Date

01/12/1996

Volume

109

Pages

329 - 332