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The synthesis of racemic 6-deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate is described. This compound is a highly potent agonist at the platelet D-myo-inositol 1,4,5-trisphosphate receptor, and it binds to the rat cerebellar receptor with an affinity equal to that of the natural ligand. These results suggest that the 5''-hydroxymethyl group of adenophostin A may contribute to its unusual potency.

Original publication

DOI

10.1016/0960-894X(96)00399-X

Type

Journal article

Journal

Bioorganic and Medicinal Chemistry Letters

Publication Date

17/09/1996

Volume

6

Pages

2197 - 2200