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2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014. The review will focus on the structure characterizations, biological properties and proposed biosynthetic processes of these compounds.

Original publication

DOI

10.3390/md12126213

Type

Journal article

Journal

Mar Drugs

Publication Date

19/12/2014

Volume

12

Pages

6213 - 6235

Keywords

Aquatic Organisms, Diketopiperazines, Dipeptides, Humans, Marine Biology