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SHIP2 is a phosphatase that acts at the 5-position of phosphatidylinositol 3,4,5-trisphosphate. It is one of several enzymes that catalyse dephosphorylation at the 5-position of phosphoinositides or inositol phosphates. SHIP2 has a confirmed role in opsismodysplasia, a disease of bone development, but also interacts with proteins involved in insulin signalling, cytoskeletal function (thus having an impact on endocytosis, adhesion, proliferation and apoptosis) and immune system function. The structure of three domains (constituting about 38 % of the protein) is known. Inhibitors of SHIP2 activity have been designed to interact with the catalytic domain with sub-micromolar IC50 values: these come from a range of structural classes and have been shown to have in vivo effects consistent with SHIP2 inhibition. Much remains unknown about the roles of SHIP2, and possible future directions for research are indicated.

Original publication

DOI

10.1002/cbic.201600541

Type

Journal article

Journal

Chembiochem

Publication Date

01/02/2017

Volume

18

Pages

233 - 247

Keywords

enzymes, inhibitors, phosphatases, phospholipids, structure, Binding Sites, Catalytic Domain, Humans, Immune System, Insulin, Ligands, Osteochondrodysplasias, Phosphatidylinositol Phosphates, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Signal Transduction