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Using a chemoenzymatic approach we synthesized a number of structurally-modified analogues of the novel Ca 2+ -releasing cyclic nucleotide cADPR. This produced novel agonists, antagonists and enzyme inhibitors to investigate this new signalling pathway, and also the first membrane permeable antagonist.

Type

Journal article

Journal

Phosphorus, Sulfur and Silicon and Related Elements

Publication Date

01/12/1999

Volume

144-146

Pages

517 - 520