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Contact of Jurkat T-lymphocytes with the extracellular matrix (ECM) protein laminin resulted in long-lasting alpha6beta1-integrin-mediated Ca(2+) signalling. Both Ca(2+) release from thapsigargin-sensitive Ca(2+) stores and capacitative Ca(2+) entry via Ca(2+) channels sensitive to SKF 96365 constitute important parts of this process. Inhibition of alpha6beta1-integrin-mediated Ca(2+) signalling by (1) the src kinase inhibitor PP2, (2) the PLC inhibitor U73122, and (3) the cyclic adenosine diphosphoribose (cADPR) antagonist 7-deaza-8-Br-cADPR indicate the involvement of src tyrosine kinases and the Ca(2+)-releasing second messengers D-myo-inositol 1,4,5-trisphosphate (InsP3) and cADPR.

Type

Journal article

Journal

Cell Signal

Publication Date

12/2001

Volume

13

Pages

895 - 899

Keywords

Adenosine Diphosphate Ribose, Calcium Channel Blockers, Calcium Signaling, Cyclic ADP-Ribose, Dose-Response Relationship, Drug, Enzyme Inhibitors, Estrenes, Humans, Imidazoles, Integrin alpha6beta1, Integrins, Jurkat Cells, Kinetics, Laminin, Pyrimidines, Pyrrolidinones, T-Lymphocytes, Thapsigargin, Type C Phospholipases, src-Family Kinases