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[structure: see text] 5'-Deoxy-5'-phenyladenophostin A (5), designed as a useful IP(3) receptor ligand based on the previous structure-activity relationship studies, was successfully synthesized via two key stereoselective glycosidation steps. This compound proved to be a highly potent IP(3) receptor agonist.

Original publication

DOI

10.1021/ol0602710

Type

Journal article

Journal

Org Lett

Publication Date

30/03/2006

Volume

8

Pages

1455 - 1458

Keywords

Adenosine, Inositol 1,4,5-Trisphosphate Receptors, Ligands, Molecular Structure, Stereoisomerism, Structure-Activity Relationship