Synthesis of [<sup>17</sup>O]‐ and [<sup>18</sup>O]‐labelled hypophosphate
Potter BVL.
The preparation of 17O‐ and 18O‐labelled hypophosphate by oxidation of diphosphite (P2‐P4 acid) with iodine‐water is described. The 162 MHz NMR 31p(18O) isotope shift of 18O‐labelled hypophosphate is 2.42 Hz (0.0149 ppm), the relatively large value compared to 18O‐pyrophosphate, 1.73 Hz (0.0107 ppm), being suggestive of an as yet unobserved 31P(18O) β‐isotope shift of 1.38 Hz (0.009 ppm) Copyright © 1989 John Wiley & Sons, Ltd.