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The soluble transcobalamin receptor (sCD320) is present in cerebrospinal fluid and correlates with the dementia-related biomarkers phospho-tau and total-tau. Here we present data on the relation of sCD320 to Alzheimer's disease and scores of cognitive tests. Lumbar cerebrospinal fluid samples from 42 pathologically-confirmed cases of Alzheimer's disease and 25 non-demented controls were analyzed for sCD320 employing an in-house ELISA. The participants' cognitive functions were tested using the Cambridge Cognition Examination (CAMCOG) and the Mini-Mental State Examination (MMSE). There was no significant difference in the median CSF sCD320 concentration between patients and controls. The median (2.5-97.5 percentiles) sCD320 for all participants (n = 67) was 15 (3-29) pmol/L. We observed a non-linear correlation between sCD320 and cognitive scores. Spearman's correlation between sCD320 and total CAMCOG scores was 0.627 (n = 16, p = .009) for CAMCOG scores ≤27, and -0.293 (n = 39, p = .071) for CAMCOG scores ≥68. Spearman's correlation between sCD320 and both the low (≤9) and high (≥16) total MMSE scores was 0.274, -0.363 (n = 18, 44), p = .272, .016, respectively. In conclusion, sCD320 cannot be employed as a biomarker for differentiating Alzheimer dementia patients from controls. Further studies are warranted to explore the non-linear correlations between sCD320 and scores of cognitive function.

Original publication

DOI

10.1080/00365513.2017.1323345

Type

Journal article

Journal

Scand j clin lab invest

Publication Date

09/2017

Volume

77

Pages

332 - 337

Keywords

CD320, Cobalamin, dementia, vitamin B12, Aged, Aged, 80 and over, Alzheimer Disease, Antigens, CD, Biomarkers, Case-Control Studies, Cognition, Cognitive Dysfunction, Humans, Intelligence Tests, Middle Aged, Solubility, Statistics, Nonparametric, Vitamin B 12