Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Great attention has been placed on the link between metabolism and immune function giving rise to the term "immunometabolism". It is widely accepted that inflammation and oxidative stress are key processes that underlie metabolic complications during obesity, diabetes and atherosclerosis. Therefore, identifying the mechanisms and mediators that are involved in the regulation of both inflammation and metabolic homeostasis is of high scientific and therapeutic interest. G protein-coupled receptors (GPCRs) that signal in response to metabolites have emerged as attractive therapeutic targets in inflammatory disease. In this review, we discuss recent findings about the physiological role of the main metabolite-sensing GPCRs, their implication in immunometabolic disorders, their principal endogenous and synthetic ligands and their potential as drug targets in inflammation and metabolic disease.

Original publication

DOI

10.1089/ars.2017.7168

Type

Journal article

Journal

Antioxid Redox Signal

Publication Date

08/11/2017