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The aim of this review is to summarize current thinking on ethanol effects on the Ca2+ homeostasis in the excitable tissue cells. It has been shown that acute exposure to ethanol decreases cytoplasmic Ca2+ concentration due to Ca2+ channels inhibition and Ca2+ pumps activation. Whereas chronic exposure to ethanol increases the intracellular Ca2+ concentration in cells due to activation of passive Ca2+ transport systems and inhibition of energy-dependent Ca2+ transport systems. The emphasis is place on a possible role of pharmacologic agents that preserve Ca2+ homeostasis in protecting against ethanol-induced diseases.

Type

Journal article

Journal

Ukr biokhim zh (1999)

Publication Date

01/2002

Volume

74

Pages

19 - 26

Keywords

Animals, Calcium, Calcium Channels, Calcium-Transporting ATPases, Ethanol, Homeostasis