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In the experiments on the impregnant estrogenized rats the effect of chronic ethanol intake on Ca(2+)-accumulative mitochondrial systems and endoplasmatic systems of myometrium was estimated. It was defined that in chronic alcohol consumption the transport activity of mitochondria Ca(2+)-accumulative systems didn't prevail over endoplasmatic reticulum Ca(2+)-accumulative activity. Therewith mitochondria and endoplasmatic Ca(2+)-transport system was essentially disturbed. In the tested conditions Mg2+, ATP-dependent sensitivity of calcium pump to oxytocin inhibiting action was shown to disappear.

Type

Journal article

Journal

Ukr biokhim zh (1999)

Publication Date

01/2001

Volume

73

Pages

118 - 124

Keywords

Adenosine Triphosphate, Animals, Calcium, Calcium-Transporting ATPases, Endoplasmic Reticulum, Ethanol, Female, Kinetics, Mitochondria, Motivation, Myometrium, Rats