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We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.

Original publication

DOI

10.1192/bjp.bp.114.152140

Type

Journal article

Journal

Br j psychiatry

Publication Date

06/2016

Volume

208

Pages

591 - 592

Keywords

Hippocampus, Humans, Leukocytes, Mononuclear, Magnetic Resonance Imaging, Psychotic Disorders, Sp1 Transcription Factor, Sp4 Transcription Factor