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The Ca2+ channel antagonists nifedipine and verapamil each significantly inhibited (50-100%) the smooth muscle contraction induced in response to either 5-hydroxytryptamine (1 microM, 5-HT) or 20 mM K+ (K(+)-physiological salt solution) in the basilar artery. Simultaneous measurements of smooth muscle membrane potential showed that changes in potential were not modified at this time. A similar inhibitory action against the smooth muscle contraction but not the depolarization to 5-HT was obtained with the putative protein kinase C and phospholipase C inhibitors, 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (10 microM, H7) and 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (70 microM, NCDC). These data indicate that 5-HT-induced Ca2+ influx through voltage sensitive channels is important for smooth muscle contraction but not depolarization in the rabbit basilar artery.

Type

Journal article

Journal

Eur j pharmacol

Publication Date

22/04/1993

Volume

235

Pages

113 - 116

Keywords

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, Animals, Basilar Artery, Calcium Channel Blockers, Carbamates, Female, Isoquinolines, Male, Membrane Potentials, Muscle Contraction, Muscle, Smooth, Vascular, Nifedipine, Phenylcarbamates, Piperazines, Potassium, Protein Kinase C, Rabbits, Serotonin, Type C Phospholipases, Verapamil