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The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that CA(2+)-activated K+ currents, in particular IAHP, are disrupted in PrP-null mice.

Type

Journal article

Journal

Neurosci Lett

Publication Date

03/05/1996

Volume

209

Pages

49 - 52

Keywords

Action Potentials, Analysis of Variance, Animals, Calcium, Charybdotoxin, Crosses, Genetic, Female, Hippocampus, In Vitro Techniques, Male, Mice, Mice, Inbred C57BL, Mice, Inbred Strains, Mice, Knockout, Potassium Channels, Prions, Pyramidal Cells, Recombination, Genetic