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The azospirones gepirone (10 mg/kg), ipsapirone (10 mg/kg) and buspirone (10 mg/kg) were examined for their effect on regional cerebral glucose utilization in conscious rats using quantitative 2-deoxy-glucose autoradiography. All three 5-HT1A partial agonists reduced glucose utilization in the hippocampus and dentate gyrus by 20-25% and increased glucose utilization by 38-65% in the lateral habenular nucleus; an important relay between striatal/limbic areas and the mid-brain raphe nuclei. The findings emphasize the potential importance of the hippocampus as a site of action for 5-HT1A receptor active drugs in vivo and also suggest that functional activity in the striatal/limbic-habenular-raphe pathway may be influenced by gepirone, ipsapirone and buspirone.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1992

Volume

106

Pages

97 - 101

Keywords

Animals, Anti-Anxiety Agents, Autoradiography, Behavior, Animal, Blood Pressure, Body Temperature, Brain Chemistry, Buspirone, Deoxyglucose, Glucose, Male, Pyrimidines, Rats, Rats, Inbred Strains