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The synthesis of zinc(II) and copper(II) complexes of an unsymmetrical bis(thiosemicarbazonato) ligand containing a reactive styrene group are reported. The compounds have been characterised by a range of techniques including reverse-phase HPLC, cyclic voltammetry, NMR, UV/Vis, electron paramagnetic resonance and fluorescence emission spectroscopy. Time-dependent density functional theory calculations have been used to assign the electronic absorption spectrum of [ZnIIATSM] and probe the nature of the fluorescent excited state. Electrochemistry experiments show that the copper(II) complex undergoes quasi-reversible one-electron reduction at biologically accessible potentials and is within the range proposed for the complex to be hypoxiaselective. The copper-64 radiolabelled complex has been prepared in aqueous solution and characterised by reversephase radio-HPLC. Cellular uptake in HeLa cells has been observed using confocal fluorescence microscopy. © Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Original publication

DOI

10.1002/ejic.200701351

Type

Journal

European Journal of Inorganic Chemistry

Publication Date

01/04/2008

Pages

1985 - 1993