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Publications

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.

Cogswell TJ. et al, (2024), RSC Med Chem

Correction: Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2).

Kennett A. et al, (2024), Chem Commun (Camb)

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

Kumar P. et al, (2024)

Small Molecule Inhibitors of Arylamine N-Acetyltransferase 1 Attenuate Cellular Respiration

Choudhury C. et al, (2024), ACS Pharmacology and Translational Science

Biased agonists of GPR84 and insights into biological control.

Luscombe VB. et al, (2023), Br J Pharmacol

Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists.

Wang P. et al, (2023), J Med Chem

Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2).

Kennett A. et al, (2023), Chem Commun (Camb)

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's.

Brimblecombe KR. et al, (2023), Eur J Neurosci

Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.

Luscombe VB. et al, (2023), Eur J Pharmacol, 956

Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.

Josa-Culleré L. et al, (2023), Eur J Med Chem, 258

Statin-activation of RyR1 is a class effect but separable from HMG-CoA reductase inhibition.

Lindsay C. et al, (2022), Br J Pharmacol

Increasing Diversity in Admissions to Postgraduate Study.

Conway SJ. et al, (2022), J Med Chem, 65, 5867 - 5869

Recent Advances in Small Molecule Stimulation of Regeneration and Repair.

Silpa L. et al, (2022), Bioorg Med Chem Lett

Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate.

Bose SJ. et al, (2022), Front Pharmacol, 13

A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo

Josa-Culleré L. et al, (2021), Journal of Medicinal Chemistry

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

Vuorinen A. et al, (2021), Eur J Med Chem, 220

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.

Partridge FA. et al, (2021), ACS Infect Dis

Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques

Chatzopoulou M. et al, (2021), ACS Medicinal Chemistry Letters

Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.

Chatzopoulou M. et al, (2020), ACS Med Chem Lett, 11, 2421 - 2427

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.

Hua P. et al, (2020), Blood, 136, 2410 - 2415

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