Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I.
Liu X. et al, (2024), Metabolism
Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
Fu L. et al, (2024), Cardiovasc Res, 120, 954 - 970
Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity.
Márquez-Moñino MÁ. et al, (2024), Nat Commun, 15
Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents
Zaraei S-O. et al, (2024), Bioorganic & Medicinal Chemistry, 117645 - 117645
Crystal Structure and Enzymology of Solanum tuberosum Inositol Tris/Tetrakisphosphate Kinase 1 (StITPK1).
Whitfield HL. et al, (2024), Biochemistry, 63, 42 - 52
Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs.
Hostachy S. et al, (2023), Chemistry, 29
Promising Drug Candidates for the Treatment of Polycystic Ovary Syndrome (PCOS) as Alternatives to the Classical Medication Metformin
Potter B. and Dohle W., (2023), European Journal of Pharmacology
2-Methoxyestradiol-3,17-O,O-bis-sulfamate (STX140) Inhibits Proliferation and Invasion via Senescence Pathway Induction in Human BRAFi-Resistant Melanoma Cells
Potter B. and Dohle W., (2023), International Journal of Molecular Sciences
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein.
Sacerdoti M. et al, (2023), Sci Signal, 16
Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP5.
Shipton ML. et al, (2023), Chem Sci, 14, 4979 - 4985
2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca2+ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis
Potter B. and Dohle W., (2023), BBA: Molecular Cell Research
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4.
Whitfield HL. et al, (2023), Biochem J, 480, 433 - 453
Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations
Siddiqui R. et al, (2023), Antibiotics, 12, 561 - 561
Itraconazole inhibits endothelial cell migration by disrupting inositol 2 pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling
Potter B. et al, (2023), Biomedicine and Pharmacotherapy
Synthesis and in vitro antimicrobial SAR of benzyl and phenyl guanidine and aminoguanidine hydrazone derivatives
Potter B. et al, (2022), Molecules
2-Difluoromethoxy-substituted Estratriene Sulfamates: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Steroid Sulfatase Inhibition
Potter B. et al, (2022), CheMedChem
Lysosomal calcium signalling contributes to acute physiological control of heart rate at the sino-atrial node pacemaker
Capel RA. et al, (2022), ACTA PHYSIOLOGICA, 236, 575 - 577
Cell fate following irradiation of MDA-MB-231- and MCF-7 breast cancer cells pre-exposed to a tetrahydroisoquinoline sulfamate microtubule disruptor
Potter B. and Dohle W., (2022), Molecules
A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop.
Wang H. et al, (2022), Nat Commun, 13
Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-Inosine 5'-Monophosphate, Analogues and Early Structure-Activity Relationship
Potter B. and Watt J., (2021), Molecules