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Publications

Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2.

Hu J. et al, (2022), J Gen Physiol, 154

The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2.

Wilson AD. et al, (2021), J Physiol, 599, 5179 - 5201

The Malignant Hyperthermia G2435R Mutation Causes Constitutive RYR1 Openings

Humberstone TM. et al, (2021), BIOPHYSICAL JOURNAL, 120, 111A - 111A

Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis: Neuro-cardiac research

Sigalas C. et al, (2020), Royal Society Open Science, 7

Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis.

Sigalas C. et al, (2020), R Soc Open Sci, 7

Impaired Ligand Regulation of Native RyR2 Channels in the Catechol-aminergic Polymorphic Ventricular Tachycardia Mutation, RyR2-V2475F(+/-)

Wilson AD. et al, (2019), BIOPHYSICAL JOURNAL, 116, 381A - 381A

Long-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex.

Rigas P. et al, (2018), Front Synaptic Neurosci, 10

High-Throughput Analysis of in-vitro LFP Electrophysiological Signals: A validated workflow/software package.

Tsakanikas P. et al, (2017), Sci Rep, 7

Sex differences in endogenous cortical network activity: spontaneously recurring Up/Down states.

Sigalas C. et al, (2017), Biol Sex Differ, 8

High-Affinity Nicotinic Receptors Modulate Spontaneous Cortical Up States In Vitro.

Sigalas C. et al, (2015), J Neurosci, 35, 11196 - 11208

Spontaneous Up states in vitro: a single-metric index of the functional maturation and regional differentiation of the cerebral cortex.

Rigas P. et al, (2015), Front Neural Circuits, 9

LONG-TERM EFFECTS OF SINGLE EARLY-LIFE SEIZURES ON CORTICAL EXCITABILITY

Rigas P. et al, (2013), EPILEPSIA, 54, 255 - 255

DEVELOPMENTAL REGULATION OF SPONTANEOUS NETWORK ACTIVITY IN MOUSE CORTICAL SLICES

Rigas P. et al, (2011), JOURNAL OF NEUROCHEMISTRY, 118, 78 - 79

EFFECTS OF AGE ON PYRAMIDAL NEURON MORPHOLOGY, VASCULATURE AND BEHAVIOUR IN A MOUSE MODEL OF ACCELERATED COGNITIVE AGING

Konsolaki E. et al, (2011), JOURNAL OF NEUROCHEMISTRY, 118, 238 - 238

Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2.

Sigalas C. et al, (2009), Biophys J, 97, 1907 - 1916

Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors.

Sigalas C. et al, (2009), Br J Pharmacol, 156, 794 - 806

Ca2+-calmodulin Increases RyR2 Open Probability Yet Reduces Ryanoid Association With RyR2

Sigalas C. et al, (2009), BIOPHYSICAL JOURNAL, 96, 110A - 110A

Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP.

Stewart R. et al, (2008), J Membr Biol, 222, 65 - 77

Ca2+-bound calmodulin (Ca2+CaM) activates the cardiac ryanodine receptor (RyR2) via a high affinity binding site and inhibits activity via a lower affinity site.

Sigalas C. and Sitsapesan R., (2007), BIOPHYSICAL JOURNAL, 88A - 88A

Calmodulin activates the cardiac ryanodine receptor (RyR2) and increases single-channel conductance at sub-activating Ca2+ levels.

Sigalas C. and Sitsapesan R., (2007), BIOPHYSICAL JOURNAL, 23A - 23A

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