Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR.
Journal article
Kühn FJP. et al, (2019), Sci Rep, 9
Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.
Journal article
Zhang B. et al, (2018), Sci Rep, 8
Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis.
Journal article
Vara D. et al, (2018), Antioxid Redox Signal, 28, 110 - 130
Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".
Journal article
Watt JM. et al, (2017), Sci Rep, 7
2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.
Journal article
Fliegert R. et al, (2017), Nat Chem Biol, 13, 1036 - 1044
Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy.
Journal article
Kyratsous NI. et al, (2017), Proc Natl Acad Sci U S A, 114, E6381 - E6389
Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.
Journal article
Fliegert R. et al, (2017), Biochem J, 474, 2159 - 2175
Designer small molecules to target calcium signalling.
Journal article
Swarbrick JM. et al, (2015), Biochem Soc Trans, 43, 417 - 425
Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.
Journal article
Swarbrick JM. et al, (2014), J Med Chem, 57, 8517 - 8529
'Click cyclic ADP-ribose': a neutral second messenger mimic.
Journal article
Swarbrick JM. et al, (2014), Chem Commun (Camb), 50, 2458 - 2461
Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.
Journal article
Moreau C. et al, (2013), J Med Chem, 56, 10079 - 10102
Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.
Journal article
Nebel M. et al, (2013), J Biol Chem, 288, 16017 - 16030
CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template.
Journal article
Moreau C. et al, (2013), PLoS One, 8
Total synthesis of a cyclic adenosine 5'-diphosphate ribose receptor agonist.
Journal article
Swarbrick JM. and Potter BVL., (2012), J Org Chem, 77, 4191 - 4197
Synthesis of 4-C-alkyl inositol 1,4,5-trisphosphates and 1,3,4,5-tetrakisphosphates.
Journal article
Swarbrick JM. and Gaffney PRJ., (2010), J Org Chem, 75, 4376 - 4386
Regioselective deprotection of orthobenzoates for the synthesis of inositol phosphates.
Journal article
Swarbrick JM. et al, (2009), Org Biomol Chem, 7, 1709 - 1715
Context-dependent calcium signaling in encephalitogenic T cells – an in vivo two-photon imaging study
Journal article
Potter BVL. and Watt JM., Proceedings of the National Academy of Sciences of USA