Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function.
Al-Hosni R. et al, (2025), Br J Pharmacol
The TMEM16A channel as a potential therapeutic target in vascular disease.
Al-Hosni R. et al, (2024), Curr Opin Nephrol Hypertens, 33, 161 - 169
Identification of determinants of lipid and ion transport in TMEM16/anoctamin proteins through a Bayesian statistical analysis.
Moran O. and Tammaro P., (2024), Biophys Chem, 308
The TMEM16A anion channel as a versatile regulator of vascular tone.
Tammaro P., (2023), Sci Signal, 16
The pharmacology of the TMEM16A channel: therapeutic opportunities.
Al-Hosni R. et al, (2022), Trends Pharmacol Sci
The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia
Korte N. et al, (2022), Journal of Clinical Investigation
TMEM16A channel is a key regulator of cerebral blood flow at the capillary level
Ilkan Z. et al, (2022), BIOPHYSICAL JOURNAL, 121, 176A - 176A
Polymodal Control of TMEM16x Channels and Scramblases
Agostinelli E. and Tammaro P., (2022), International Journal of Molecular Sciences, 23
An outer-pore gate modulates the pharmacology of the TMEM16A channel.
Dinsdale RL. et al, (2021), Proc Natl Acad Sci U S A, 118
Ion channels as convergence points in the pathology of pulmonary arterial hypertension.
Jouen-Tachoire TRH. et al, (2021), Biochem Soc Trans
The Molecular Basis of the Regulation of the TMEM16A Ca2+-Activated Cl- Channel by the Lysosomal NPC1 Protein
Scofano LF. et al, (2021), BIOPHYSICAL JOURNAL, 120, 247A - 247A
Lipid-mediated control of the TMEM16A Ca2+- gated Cl- channel by the lysosomal NPC1 protein
Scofano LF. et al, (2021), BRITISH JOURNAL OF PHARMACOLOGY, 178, 414 - 414
Molecular Mechanism of Modulation of the TMEM16A Channel by Anthracene-9-Carboxylic Acid: Implications for Channel Gating
Dinsdale R. et al, (2020), BIOPHYSICAL JOURNAL, 118, 325A - 325A
Control of cerebral blood flow by capillary pericytes in Alzheimer's disease
Korte N. et al, (2019), ACTA PHYSIOLOGICA, 227
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Bushell SR. et al, (2019), Nat Commun, 10
The Ca2+-gated Cl- channel TMEM16A is a crucial mediator of pericyte contraction in the CNS microvasculature
Korte N. et al, (2019), GLIA, 67, E649 - E649
Inhibition of TMEM16A by Docosahexaenoic Acid Plays a Crucial Role in Blood Vessel Relaxation
Acheson KE. and Tammaro P., (2019), BIOPHYSICAL JOURNAL, 116, 172A - 172A
Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2.
Rorsman NJG. et al, (2018), Br J Pharmacol, 175, 2028 - 2045
Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels.
Ta CM. et al, (2017), Br J Pharmacol, 174, 2984 - 2999