Development of a fluorescence-based assay for RecBCD activity using Functional Data Analysis and Design of Experiments
Winnifrith A. et al, (2025), RSC Chemical Biology
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.
Ritzefeld M. et al, (2024), J Med Chem, 67, 1061 - 1078
Development of an inhibitor of the mutagenic SOS response that suppresses the evolution of quinolone antibiotic resistance
Bradbury JD. et al, (2024), Chemical Science
Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Jamshidiha M. et al, (2022), RSC medicinal chemistry, 13, 150 - 155
Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay.
Andrei SA. et al, (2022), 2374, 13 - 26
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE. et al, (2021), Mol Cell, 81, 5025 - 5038.e10
Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)**
Lanyon‐Hogg T. et al, (2021), Angewandte Chemie, 133, 13654 - 13659
Photochemical probe identification of a small-molecule inhibitor binding site in Hedgehog acyltransferase (HHAT)
Lanyon-Hogg T. et al, (2021), Angewandte Chemie International Edition
Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors.
Lanyon-Hogg T., (2021), Future Med Chem, 13, 143 - 155
Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity".
Panyain N. et al, (2020), Journal of the American Chemical Society, 142
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity
Panyain N. et al, (2020), J Am Chem Soc, 142, 12020 - 12026
Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes.
Lanyon-Hogg T. et al, (2019), Chem Sci, 10, 8995 - 9000
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics
Storck EM. et al, (2019), Nat Chem, 11, 552 - 561
Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
Lim CSQ. et al, (2019), Bioorg Med Chem, 27
Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
Clulow JA. et al, (2017), Chem Commun (Camb), 53, 5182 - 5185
Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design
Zhao W. et al, (2017), Curr Top Med Chem, 17, 16 - 29