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  • Rhythmic networks in the brain that help us find our way in the world

    The Somogyi group discovered a rhythmic subcortical inhibitory (GABAergic) nerve cell population in a part of the mouse brain called the medial septum that projects to both the dorsal presubiculum and entorhinal cortex but avoids the hippocampus. As set out in a recent paper published in eLife, the group named these nerve cells ‘orchid cells’ based on the shape of the axonal trajectories

  • The heart’s own adrenaline-producing cells can control heart rhythm

    The group led by Ming Lei has discovered that the heart can regulate its own rhythm by releasing adrenaline (epinephrine) from a specialised kind of heart muscle cell that contains the enzyme that makes adrenaline.

  • Transcriptome analysis from a small number of neurons purified from the aged mouse brain

    The Minichiello Group in collaboration with the Nerlov laboratory and FACS facility at the MRC Weatherall Institute of Molecular Medicine, has established new methods to isolate brain neurons from the adult and aged mouse. This makes it possible to perform unbiased studies of aging brain neurons from relatively small numbers of neurons by quantitative transcriptome analysis, such as RNA sequencing, that offers higher resolution than other methods.