Growing up as a Pharmacologist
Access David's podcast here:
http://podcasts.ox.ac.uk/growing-pharmacologist-during-more-half-century-department
A David Smith
MA, DPhil, FMedSci
Professor Emeritus of Pharmacology
- Founding Director OPTIMA
- Founding Director MRC Anatomical Neuropharmacology Unit.
I have spent my entire academic career in the University of Oxford, graduating from Christ Church in Biochemistry in 1963 from where I joined the Department of Pharmacology to do research for a D.Phil.
From 1971-84 I was University Lecturer in Pharmacology at Oxford and Student (Fellow) of Christ Church. From 1976 to 2001 I was founding Chief Editor of IBRO’s journal Neuroscience. I was awarded the Gaddum prize medal of the British Pharmacological Society in 1979. From 1984-2005 I was Chair and Head of Pharmacology at Oxford and Fellow of Lady Margaret Hall. In 1985 the MRC established the Anatomical Neuropharmacology Unit associated with the Department with me as Honorary Director and Peter Somogyi FRS as Associate Director. In 1987 I negotiated an agreement with ER Squibb & Sons Inc., which led to the donation of £20 million to the University in order to provide the current new building for the Department of Pharmacology and funding for research projects in brain disease. In 1988 I co-founded the Oxford Project to Investigate Memory and Aging (OPTIMA). I was Deputy-Head (Vice-Dean) of the newly established Division of Medical Sciences at Oxford from 2000-2005.
I have honorary doctorates from the Universities of Szeged and Lund and am a member of the Hungarian and Norwegian Academies of Science. In 2000 I was elected Fellow of the Academy of Medical Sciences, UK. In 2006 I was made the first Honorary Research Fellow of Alzheimer’s Research UK, having served for 5 years as the first Chair of their Scientific Advisory Board. After retiring I have continued my research into the prevention of Alzheimer’s disease.
However, I no longer have any research facilities in the Department and so cannot take on any students or visitors
Key publications
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Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment.
Journal article
Douaud G. et al, (2013), Proc Natl Acad Sci U S A, 110, 9523 - 9528
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Homocysteine, B Vitamins, and Cognitive Impairment.
Journal article
Smith AD. and Refsum H., (2016), Annu Rev Nutr, 36, 211 - 239
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Dementia Prevention by Disease-Modification through Nutrition.
Journal article
Smith AD. and Refsum H., (2017), J Prev Alzheimers Dis, 4, 138 - 139
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Homocysteine and Dementia: An International Consensus Statement.
Journal article
Smith AD. et al, (2018), J Alzheimers Dis, 62, 561 - 570
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Dementia (including Alzheimer's disease) can be prevented: statement supported by international experts.
Journal article
Smith AD. and Yaffe K., (2014), J Alzheimers Dis, 38, 699 - 703
Recent publications
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Mandatory food fortification with folic acid.
Journal article
Smith AD. et al, (2022), Lancet Glob Health, 10
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Maternal and infant vitamin B12 status and development.
Journal article
Smith AD., (2018), Pediatr Res, 84, 591 - 592
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Homocysteine and Dementia: An International Consensus Statement.
Journal article
Smith AD. et al, (2018), J Alzheimers Dis, 62, 561 - 570
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Vitamin B<inf>12</inf>
Journal article
Smith AD. et al, (2018), 83, 215 - 279
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Elevated homocysteine and N-methyl-d-aspartate-receptor antibodies as a cause of behavioural and cognitive decline in 22q11.2 deletion syndrome.
Journal article
Vann Jones S. et al, (2017), Oxf Med Case Reports, 2017
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The soluble transcobalamin receptor (sCD320) in relation to Alzheimer's disease and cognitive scores.
Journal article
Abuyaman O. et al, (2017), Scand J Clin Lab Invest, 77, 332 - 337
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Folic Acid for the Prevention of Neural Tube Defects.
Journal article
Refsum H. and Smith AD., (2017), JAMA Pediatr, 171, 710 - 711